Article
Altered O-glycosylation of β1-adrenergic receptor N-terminal single-nucleotide variants modulates receptor processing and functional activity.
The FEBS journal - 1 Mar 2025
Tuhkanen Hanna E, Haasiomäki Ilona J, Lackman Jarkko J, Goth Christoffer K, Mattila S Orvokki, Ye Zilu, Vakhrushev Sergey Y, Magga Johanna, Kerkelä Risto, Clausen Henrik, Schjoldager Katrine T, Petäjä-Repo Ulla E
Abstract excerpt
N-terminal nonsynonymous single-nucleotide polymorphisms (SNPs) of G protein-coupled receptors (GPCRs) are common and often affect receptor post-translational modifications. Their functional implications are, however, largely unknown. We have previously shown that the human β1-adrenergic receptor (β1AR) is O-glycosylated in the N-terminal extracellular domain by polypeptide GalNAc transferase-2 that co-regulates...
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