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Article

Genome-wide interaction study of dust mite allergen on lung function in children with asthma.

The Journal of allergy and clinical immunology - 1 Oct 2017

Forno Erick, Sordillo Joanne, Brehm John, Chen Wei, Benos Takis, Yan Qi, Avila Lydiana, Soto-Quirós Manuel, Cloutier Michelle M, Colón-Semidey Angel, Alvarez Maria, Acosta-Pérez Edna, Weiss Scott T, Litonjua Augusto A, Canino Glorisa, Celedón Juan C

Abstract excerpt

BACKGROUND: Childhood asthma is likely the result of gene-by-environment (G × E) interactions. Dust mite is a known risk factor for asthma morbidity. Yet, there have been no genome-wide G × E studies of dust mite allergen on asthma-related phenotypes. OBJECTIVE: We sought to identify genetic variants whose effects on lung function in children with asthma are modified by the level of dust mite allergen exposure....

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Identifiers

PMID: 28167095
DOI: 10.1016/j.jaci.2016.12.967
PMCID: PMC5544591

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