Article
Whole-Genome Sequencing Identifies Novel Functional Loci Associated with Lung Function in Puerto Rican Youth.
American journal of respiratory and critical care medicine - 1 Oct 2020
Lee Eunice Y, Mak Angel C Y, Hu Donglei, Sajuthi Satria, White Marquitta J, Keys Kevin L, Eckalbar Walter, Bonser Luke, Huntsman Scott, Urbanek Cydney, Eng Celeste, Jain Deepti, Abecasis Gonçalo, Kang Hyun M, Germer Soren, Zody Michael C, Nickerson Deborah A, Erle David, Ziv Elad, Rodriguez-Santana Jose, Seibold Max A, Burchard Esteban G
Abstract excerpt
Rationale: Puerto Ricans have the highest childhood asthma prevalence in the United States (23.6%); however, the etiology is uncertain.Objectives: In this study, we sought to uncover the genetic architecture of lung function in Puerto Rican youth with and without asthma who were recruited from the island (n = 836).Methods: We used admixture-mapping and whole-genome sequencing data to discover genomic regions...
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