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Article

Genome-wide association study in minority children with asthma implicates DNAH5 in bronchodilator responsiveness.

Scientific reports - 22 Jul 2022

Joo Jaehyun, Mak Angel C Y, Xiao Shujie, Sleiman Patrick M, Hu Donglei, Huntsman Scott, Eng Celeste, Kan Mengyuan, Diwakar Avantika R, Lasky-Su Jessica A, Weiss Scott T, Sordillo Joanne E, Wu Ann C, Cloutier Michelle, Canino Glorisa, Forno Erick, Celedón Juan C, Seibold Max A, Hakonarson Hakon, Williams L Keoki, Burchard Esteban G, Himes Blanca E

Abstract excerpt

Variability in response to short-acting β2-agonists (e.g., albuterol) among patients with asthma from diverse racial/ethnic groups may contribute to asthma disparities. We sought to identify genetic variants associated with bronchodilator response (BDR) to identify potential mechanisms of drug response and risk factors for worse asthma outcomes. Genome-wide association studies of bronchodilator response (BDR)...

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Asthma
Axonemal Dyneins
Bronchodilator Agents
Ethnicity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome-Wide Association Study

Hispanic or Latino

Mexican Americans

Minority Groups

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Open in PubMed Open full text

Identifiers

PMID: 35869121
DOI: 10.1038/s41598-022-16488-6
PMCID: PMC9307508

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