Genome-wide association study reveals class I MHC-restricted T cell-associated molecule gene (CRTAM) variants interact with vitamin D levels to affect asthma exacerbations.

Abstract excerpt

BACKGROUND: It has recently been shown that vitamin D deficiency can increase asthma development and severity and that variations in vitamin D receptor genes are associated with asthma susceptibility. OBJECTIVE: We sought to find genetic factors that might interact with vitamin D levels to affect the risk of asthma exacerbation. METHODS: We conducted a genome-wide study of gene-vitamin D interaction on asthma...

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