Article
Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations.
The Journal of allergy and clinical immunology - 1 Jul 2008
Hunninghake Gary M, Soto-Quirós Manuel E, Lasky-Su Jessica, Avila Lydiana, Ly Ngoc P, Liang Catherine, Klanderman Barbara J, Raby Benjamin A, Gold Diane R, Weiss Scott T, Celedón Juan C
Abstract excerpt
BACKGROUND: The allergenicity of dust mite exposure might be dependent on variants in the gene for IL-10 (IL10). OBJECTIVES: To evaluate whether dust mite exposure modifies the effect of single nucleotide polymorphisms (SNPs) in IL10 on allergy and asthma exacerbations. METHODS: We genotyped 6 SNPs in IL10 in 417 Costa Rican children and 503 white children in the Childhood Asthma Management Program (CAMP) with...
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