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Article

Reversible thiol oxidation in the H2O2-dependent activation of the transcription factor Pap1.

Journal of cell science - 15 May 2013

Calvo Isabel A, Ayté José, Hidalgo Elena

Abstract excerpt

Reversible thiol oxidation is both a mark of hydrogen peroxide (H2O2) toxicity and an initiator of signalling events. H2O2 sensors contain exposed and reactive cysteine residues, which become transiently oxidized as an activation mechanism. In fission yeast, the Pap1 (pombe AP-1) transcription factor is normally cytosolic, and upon H2O2 stress it undergoes post-translational modifications impairing its nuclear...

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PMID: 23525001
DOI: 10.1242/jcs.124370

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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