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The spliced leader RNA silencing (SLS) pathway in <i>Trypanosoma brucei</i> is induced by perturbations of endoplasmic reticulum, Golgi, or mitochondrial proteins factors and functional analysis of SLS inducing kinase, PK3

2021-09-08

Abstract excerpt

<h4>ABSTRACT</h4> In the parasite Trypanosoma brucei , the causative agent of human African sleeping sickness, all mRNAs are trans -spliced to generate a common 5’ exon derived from the spliced leader RNA (SL RNA). Perturbations of protein translocation across the endoplasmic reticulum (ER) induce the spliced leader RNA silencing (SLS) pathway. SLS activation is mediated by a serine-threonine kinase, PK3, which...

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Literature Corpus work
7303c211-880f-5bb9-9a05-2f56b1fa95b6
DOI
10.1101/2021.09.07.459367
Open publication

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