Article
The arachidonate 5-lipoxygenase activating protein gene polymorphism is associated with the risk of scleroderma-related interstitial lung disease: a multicentre European Scleroderma Trials and Research group (EUSTAR) study.
Rheumatology (Oxford, England) - 1 May 2017
Kowal-Bielecka Otylia, Chwiesko-Minarowska Sylwia, Bernatowicz Pawel L, Allanore Yannick, Radstake Timothy, Matucci-Cerinic Marco, Broen Jasper, Hesselstrand Roger, Krasowska Dorota, Riemekasten Gabriella, Vonk Madelon, Kowalczuk Oksana, Bielecki Marek, Milewski Robert, Chyczewski Lech, Niklinski Jacek, Kowal Krzysztof
Abstract excerpt
Objectives: The arachidonate 5-lipoxygenase activating protein (ALOX5AP) regulates synthesis of leukotrienes (LTs), which are important mediators of inflammation and connective tissue remodelling. The aim of this study was to evaluate if single nucleotide polymorphisms (SNPs) of ALOX5AP confer risk of SSc and/or SSc-related organ involvement. Methods: Seven SNPs of ALOX5AP (rs17222814, rs17216473, rs10507391,...
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