Article
Polymorphisms in TBX21 and STAT4 increase the risk of systemic sclerosis: evidence of possible gene-gene interaction and alterations in Th1/Th2 cytokines.
Arthritis and rheumatism - 1 Dec 2009
Gourh Pravitt, Agarwal Sandeep K, Divecha Dipal, Assassi Shervin, Paz Gene, Arora-Singh Rajpreet K, Reveille John D, Shete Sanjay, Mayes Maureen D, Arnett Frank C, Tan Filemon K
Abstract excerpt
OBJECTIVE: Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin and internal organs. Dysregulation of the immune system, including the Th1/Th2 cytokine balance, is central to the pathogenesis of SSc. This study was undertaken to investigate the hypothesis that single-nucleotide polymorphisms (SNPs) in TBX21 and STAT4, both of which are critical transcription factors that...
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