Article
Up-regulated expression of HLA-DRB5 transcripts and high frequency of the HLA-DRB5*01:05 allele in scleroderma patients with interstitial lung disease.
Rheumatology (Oxford, England) - 1 Oct 2012
Odani Toshio, Yasuda Shinsuke, Ota Yuko, Fujieda Yuichiro, Kon Yujiro, Horita Tetsuya, Kawaguchi Yasushi, Atsumi Tatsuya, Yamanaka Hisashi, Koike Takao
Abstract excerpt
OBJECTIVE: Interstitial lung disease (ILD) is a serious complication of SSc. We aimed to identify markers associated with SSc-related ILD. METHODS: RNA was prepared from the peripheral blood mononuclear cells of 14 SSc patients, divided into four different RNA pools according to the presence or absence of ILD and to the treatment, and subjected to microarray analysis. Real-time quantitative PCR was used to...
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