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Article

Phenotypic screening of cannabinoid receptor 2 ligands shows different sensitivity to genotype.

Biochemical pharmacology - 15 Apr 2017

Hillger Julia M, le Roy Beau, Wang Zi, Mulder-Krieger Thea, Boomsma Dorret I, Slagboom P Eline, Danen Erik H J, IJzerman Adriaan P, Heitman Laura H

Abstract excerpt

The Cannabinoid Receptor 2 (CB2R) is a G protein-coupled receptor (GPCR) investigated intensively as therapeutic target, however no drug has reached the market yet. We investigated personal differences in CB2R drug responses using a label-free whole-cell assay (xCELLigence) combined with cell lines (Lymphoblastoid Cell Lines) from individuals with varying CB2R genotypes. Responses to agonists, partial agonists...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Cannabinoid, CB2

Source

Identifiers

PMID: 28159624
DOI: 10.1016/j.bcp.2017.01.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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