Article
Getting personal: Endogenous adenosine receptor signaling in lymphoblastoid cell lines.
Biochemical pharmacology - 1 Sept 2016
Hillger J M, Diehl C, van Spronsen E, Boomsma D I, Slagboom P E, Heitman L H, IJzerman A P
Abstract excerpt
Genetic differences between individuals that affect drug action form a challenge in drug therapy. Many drugs target G protein-coupled receptors (GPCRs), and a number of receptor variants have been noted to impact drug efficacy. This, however, has never been addressed in a systematic way, and, hence, we studied real-life genetic variation of receptor function in personalized cell lines. As a showcase we studied...
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