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Increased BACE1-AS long noncoding RNA and β-amyloid levels in heart failure

30 Jan 2017

Abstract excerpt

AIMS: Antisense long noncoding RNAs (ncRNAs) are transcripts emerging from the opposite strand of a coding-RNA region and their role in heart failure (HF) is largely unknown. Additionally, HF and Alzheimer's disease (AD) share several non-genetic effectors and risk factors. We investigated the regulation of the β-secretase-1 (BACE1) gene and of its antisense transcript BACE1-AS in ischaemic HF. METHODS AND...

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PMID: 28158647
DOI: 10.1093/cvr/cvx013

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