Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protein aggregates and novel presenilin gene variants in idiopathic dilated cardiomyopathy.

Circulation - 16 Mar 2010

Gianni Davide, Li Airong, Tesco Giuseppina, McKay Kenneth M, Moore John, Raygor Kunal, Rota Marcello, Gwathmey Judith K, Dec G William, Aretz Thomas, Leri Annarosa, Semigran Marc J, Anversa Piero, Macgillivray Thomas E, Tanzi Rudolph E, del Monte Federica

Abstract excerpt

BACKGROUND: Heart failure is a debilitating condition resulting in severe disability and death. In a subset of cases, clustered as idiopathic dilated cardiomyopathy (iDCM), the origin of heart failure is unknown. In the brain of patients with dementia, proteinaceous aggregates and abnormal oligom...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid
Share to Amyloid beta-Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium

Share to Cardiomyopathy, Dilated

Share to Immunohistochemistry

Share to Presenilin-1

Share to Presenilin-2

Share to Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 20194882
DOI: 10.1161/CIRCULATIONAHA.109.879510
PMCID: PMC2844798

Genes

PSEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20194882-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protein aggregates and novel presenilin gene variants in idiopathic dilated cardiomyopathy.PMID 20194882Read ↗

Mutations of presenilin genes in dilated cardiomyopathy and heart failure.Semantic proximity Read ↗

Presenilin-1 ΔE9 mutation associated sarcoplasmic reticulum leak alters [Ca2+]i distribution in human iPSC-derived cardiomyocytes.Semantic proximity Read ↗

Protein Aggregation Is an Early Manifestation of Phospholamban p.(Arg14del)-Related Cardiomyopathy: Development of PLN-R14del-Related Cardiomyopathy.Semantic proximity Read ↗

P62-positive aggregates are homogenously distributed in the myocardium and associated with the type of mutation in genetic cardiomyopathy.Semantic proximity Read ↗

Role of the Alpha-B-Crystallin Protein in Cardiomyopathic Disease.Semantic proximity Read ↗

Peripherally expressed misfolded proteins remotely disrupt brain function and aggravate stroke-induced brain injurySemantic proximity Read ↗

Carvedilol suppresses ryanodine receptor-dependent Ca <sup>2+</sup> bursts in human neurons bearing <i>PSEN1</i> variants found in early onset Alzheimer’s diseaseSemantic proximity Read ↗

Role of the Alpha-B-Crystallin Protein in Cardiomyopathic DiseaseSemantic proximity Read ↗

Multiple effects of SERCA2b mutations associated with Darier's disease.Semantic proximity Read ↗

Pore-Forming Proteins as Mediators of Novel Epigenetic Mechanism of EpilepsySemantic proximity Read ↗

Expression of expanded GGC repeats within NOTCH2NLC causes cardiac dysfunction in mouse modelsSemantic proximity Read ↗

Autoantibodies in patients with arrhythmogenic cardiomyopathy activate GSK-3β resulting in a loss of cardiomyocyte cohesionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.