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Article

Evolving Mutational Buildup in HIV-1 Protease Shifts Conformational Dynamics to Gain Drug Resistance.

Journal of chemical information and modeling - 26 Jun 2023

Souffrant Michael, Yao Xin-Qiu, Hamelberg Donald

Abstract excerpt

Drug resistance in antiviral treatments is a serious public health problem. Viral proteins mutate very fast, giving them a way to escape drugs by lowering drug binding affinity but with compromised function. Human immunodeficiency virus type I (HIV-1) protease, a critical antiretroviral therapeutic target, represents a model for such viral regulation under inhibition. Drug inhibitors of HIV-1 protease lose...

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Identifiers

PMID: 37285207
DOI: 10.1021/acs.jcim.3c00535
PMCID: PMC10302472

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