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Article

Predicting drug resistance of the HIV-1 protease using molecular interaction energy components.

Proteins - 1 Mar 2009

Hou Tingjun, Zhang Wei, Wang Jian, Wang Wei

Abstract excerpt

Drug resistance significantly impairs the efficacy of AIDS therapy. Therefore, precise prediction of resistant viral mutants is particularly useful for developing effective drugs and designing therapeutic regimen. In this study, we applied a structure-based computational approach to predict mutants of the HIV-1 protease resistant to the seven FDA approved drugs. We analyzed the energetic pattern of the...

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Share to Darunavir
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18704937
DOI: 10.1002/prot.22192
PMCID: PMC3210569

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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