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Article

Single nucleotide polymorphisms in the FcγR3A and TAP1 genes impact ADCC in cynomolgus monkey PBMCs.

Immunogenetics - 1 Apr 2017

Sanford Jonathan C, Wu Hong, Abdiche Yasmina, Harney Julie A, Chaparro-Riggers Javier, Adkins Karissa

Abstract excerpt

Phenotypic variability is often observed in cynomolgus monkeys on preclinical studies and may, in part, be driven by genetic variability. However, the role of monkey genetic variation remains largely unexplored in the context of drug response. This study evaluated genetic variation in cynomolgus monkey FcγR3A and TAP1 genes and the potential impact of identified polymorphisms on antibody-dependent cell-mediated...

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Share to Antibodies, Monoclonal
Share to Antibody-Dependent Cell Cytotoxicity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily B, Member 2

Share to Histocompatibility Antigens Class I

Share to Killer Cells, Natural

Share to Leukocytes, Mononuclear

Share to Macaca fascicularis

Share to Receptors, IgG

Source

Identifiers

PMID: 28154890
DOI: 10.1007/s00251-017-0970-1

Genes

TAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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