Article
Fc gamma receptor 3a genotype predicts overall survival in follicular lymphoma patients treated on SWOG trials with combined monoclonal antibody plus chemotherapy but not chemotherapy alone.
Haematologica - 1 Jun 2012
Persky Daniel O, Dornan David, Goldman Bryan H, Braziel Rita M, Fisher Richard I, Leblanc Michael, Maloney David G, Press Oliver W, Miller Thomas P, Rimsza Lisa M
Abstract excerpt
BACKGROUND: Fc gamma receptor polymorphisms were linked to outcome in follicular lymphoma patients treated with single-agent rituximab, an anti-CD20 monoclonal antibody. In particular, 158F/F genotype of Fc gamma receptor 3A and 131R/R genotype of Fc gamma receptor 2A correlated with worse outcome compared to high-affinity 158V/V and 131H/H, respectively. We examined this association in the context of anti-CD20...
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