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Article

Extracellular Loops Are Essential for the Assembly and Function of Polycystin Receptor-Ion Channel Complexes.

The Journal of biological chemistry - 10 Mar 2017

Salehi-Najafabadi Zahra, Li Bin, Valentino Victoria, Ng Courtney, Martin Hannah, Yu Yang, Wang Zhifei, Kashyap Parul, Yu Yong

Abstract excerpt

Polycystin complexes, or TRPP-PKD complexes, made of transient receptor potential channel polycystin (TRPP) and polycystic kidney disease (PKD) proteins, play key roles in coupling extracellular stimuli with intracellular Ca2+ signals. For example, the TRPP2-PKD1 complex has a crucial function in renal physiology, with mutations in either protein causing autosomal dominant polycystic kidney disease. In contrast,...

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Source

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Identifiers

PMID: 28154010
DOI: 10.1074/jbc.M116.767897
PMCID: PMC5354480

Genes

PKD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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