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Structural and molecular basis of the assembly of the TRPP2/PKD1 complex

25 Jun 2009

Abstract excerpt

Mutations in PKD1 and TRPP2 account for nearly all cases of autosomal dominant polycystic kidney disease (ADPKD). These 2 proteins form a receptor/ion channel complex on the cell surface. Using a combination of biochemistry, crystallography, and a single-molecule method to determine the subunit composition of proteins in the plasma membrane of live cells, we find that this complex contains 3 TRPP2 and 1 PKD1. A...

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PMID: 19556541
DOI: 10.1073/pnas.0903684106

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