Article
Development of a Reporter System for In Vivo Monitoring of γ-Secretase Activity in Drosophila.
Molecules and cells - 1 Jan 2017
Hong Young Gi, Roh Seyun, Paik Donggi, Jeong Sangyun
Abstract excerpt
The γ-secretase complex represents an evolutionarily conserved family of transmembrane aspartyl proteases that cleave numerous type-I membrane proteins, including the β-amyloid precursor protein (APP) and the receptor Notch. All known rare mutations in APP and the γ-secretase catalytic component, presenilin, which lead to increased amyloid βpeptide production, are responsible for early-onset familial Alzheimer's...
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