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Article

Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 21 Apr 2004

Greeve Isabell, Kretzschmar Doris, Tschäpe Jakob-Andreas, Beyn Anika, Brellinger Claire, Schweizer Michaela, Nitsch Roger M, Reifegerste Rita

Abstract excerpt

Beta-amyloid peptides that are cleaved from the amyloid precursor protein (APP) play a critical role in Alzheimer's disease (AD) pathophysiology. Here, we show that in Drosophila, the targeted expression of the key genes of AD, APP, the beta-site APP-cleaving enzyme BACE, and the presenilins led to the generation of beta-amyloid plaques and age-dependent neurodegeneration as well as to semilethality, a shortened...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15102905
DOI: 10.1523/JNEUROSCI.0283-04.2004
PMCID: PMC6729409

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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