Article
Transgenic Drosophila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype.
Proceedings of the National Academy of Sciences of the United States of America - 10 Nov 1998
Fossgreen A, Brückner B, Czech C, Masters C L, Beyreuther K, Paro R
Abstract excerpt
The importance of the amyloid precursor protein (APP) in the pathogenesis of Alzheimer's disease (AD) became apparent through the identification of distinct mutations in the APP gene, causing early onset familial AD with the accumulation of a 4-kDa peptide fragment (betaA4) in amyloid plaques and...
Topics
- Amyloid Precursor Protein Secretases
- Amyloid beta-Protein Precursor
- Animals
- Animals, Genetically Modified
- Aspartic Acid Endopeptidases
- Cell Adhesion
- Drosophila melanogaster
- Endopeptidases
- Gene Expression Regulation
- Genes, Insect
- Humans
- Phenotype