Article
Differential effect of D623N variant and wild-type Na(v)1.7 sodium channels on resting potential and interspike membrane potential of dorsal root ganglion neurons.
Brain research - 5 Sept 2013
Ahn Hye-Sook, Vasylyev Dmytro V, Estacion Mark, Macala Lawrence J, Shah Palak, Faber Catharina G, Merkies Ingemar S J, Dib-Hajj Sulayman D, Waxman Stephen G
Abstract excerpt
Sodium channel NaV1.7 is preferentially expressed in dorsal root ganglion (DRG) and sympathetic ganglion neurons. Gain-of-function NaV1.7 mutations/variants have been identified in the painful disorders inherited erythromelalgia and small-fiber neuropathy (SFN). DRG neurons transfected with these...
Topics
- Animals
- Asparagine
- Aspartic Acid
- Biophysics
- Cells, Cultured
- Computer Simulation
- Electric Stimulation
- Ganglia, Spinal
- Green Fluorescent Proteins
- Humans
- Membrane Potentials
- Models, Neurological
- Mutation
- NAV1.7 Voltage-Gated Sodium Channel