Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential effect of D623N variant and wild-type Na(v)1.7 sodium channels on resting potential and interspike membrane potential of dorsal root ganglion neurons.

Brain research - 5 Sept 2013

Ahn Hye-Sook, Vasylyev Dmytro V, Estacion Mark, Macala Lawrence J, Shah Palak, Faber Catharina G, Merkies Ingemar S J, Dib-Hajj Sulayman D, Waxman Stephen G

Abstract excerpt

Sodium channel NaV1.7 is preferentially expressed in dorsal root ganglion (DRG) and sympathetic ganglion neurons. Gain-of-function NaV1.7 mutations/variants have been identified in the painful disorders inherited erythromelalgia and small-fiber neuropathy (SFN). DRG neurons transfected with these channel variants display depolarized resting potential, reduced current-threshold, increased firing-frequency and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aspartic Acid
Share to Cells, Cultured

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Computer Simulation

Share to Membrane Potentials

Share to Mutation

Share to Neurons

Share to Rats, Sprague-Dawley

Source

Identifiers

PMID: 23850641
DOI: 10.1016/j.brainres.2013.07.005

Genes

SFN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential effect of D623N variant and wild-type Na(v)1.7 sodium channels on resting potential and interspike membrane potential of dorsal root ganglion neurons.PMID 23850641Read ↗

Nonlinear effects of hyperpolarizing shifts in activation of mutant Nav1.7 channels on resting membrane potential.Semantic proximity Read ↗

Atypical changes in DRG neuron excitability and complex pain phenotype associated with a Nav1.7 mutation that massively hyperpolarizes activation.Semantic proximity Read ↗

Na(V)1.7 mutant A863P in erythromelalgia: effects of altered activation and steady-state inactivation on excitability of nociceptive dorsal root ganglion neurons.Semantic proximity Read ↗

Depolarized inactivation overcomes impaired activation to produce DRG neuron hyperexcitability in a Nav1.7 mutation in a patient with distal limb pain.Semantic proximity Read ↗

Dynamic-clamp analysis of wild-type human Nav1.7 and erythromelalgia mutant channel L858H.Semantic proximity Read ↗

Biophysical Characterization of the human Nav1.9 sodium channel in trigeminal ganglia and dorsal root ganglia neuronsSemantic proximity Read ↗

A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons.Semantic proximity Read ↗

Sodium channel NaV1.9 mutations associated with insensitivity to pain dampen neuronal excitabilitySemantic proximity Read ↗

Neuropathy-associated Nav1.7 variant I228M impairs integrity of dorsal root ganglion neuron axons.Semantic proximity Read ↗

NaV1.7 gain-of-function mutations as a continuum: A1632E displays physiological changes associated with erythromelalgia and paroxysmal extreme pain disorder mutations and produces symptoms of both disorders.Semantic proximity Read ↗

Effects of ranolazine on wild-type and mutant hNav1.7 channels and on DRG neuron excitability.Semantic proximity Read ↗

Functional profiles of SCN9A variants in dorsal root ganglion neurons and superior cervical ganglion neurons correlate with autonomic symptoms in small fibre neuropathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.