Article
USP40 gene knockdown disrupts glomerular permeability in zebrafish.
American journal of physiology. Renal physiology - 1 Apr 2017
Takagi Hisashi, Nishibori Yukino, Katayama Kan, Katada Tomohisa, Takahashi Shohei, Kiuchi Zentaro, Takahashi Shin-Ichiro, Kamei Hiroyasu, Kawakami Hayato, Akimoto Yoshihiro, Kudo Akihiko, Asanuma Katsuhiko, Takematsu Hiromu, Yan Kunimasa
Abstract excerpt
Unbiased transcriptome profiling and functional genomics approaches have identified ubiquitin-specific protease 40 (USP40) as a highly specific glomerular transcript. This gene product remains uncharacterized, and its biological function is completely unknown. Here, we showed that mouse and rat glomeruli exhibit specific expression of the USP40 protein, which migrated at 150 kDa and was exclusively localized in...
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