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Article

Genome-wide suppressor screen identifies USP35/USP38 as therapeutic candidates for ciliopathies.

JCI insight - 14 Nov 2019

Tsai I-Chun, Adams Kevin A, Tzeng Joyce A, Shennib Omar, Tan Perciliz L, Katsanis Nicholas

Abstract excerpt

The ciliopathies are a group of phenotypically overlapping disorders caused by structural or functional defects in the primary cilium. Although disruption of numerous signaling pathways and cellular trafficking events have been implicated in ciliary pathology, treatment options for affected individuals remain limited. Here, we performed a genome-wide RNAi (RNA interference) screen to identify genetic suppressors...

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Identifiers

PMID: 31723061
DOI: 10.1172/jci.insight.130516
PMCID: PMC6948861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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