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Article

The CYP3A biomarker 4β-hydroxycholesterol does not improve tacrolimus dose predictions early after kidney transplantation.

British journal of clinical pharmacology - 1 Jul 2017

Størset Elisabet, Hole Kristine, Midtvedt Karsten, Bergan Stein, Molden Espen, Åsberg Anders

Abstract excerpt

AIMS: Tacrolimus is a cornerstone in modern immunosuppressive therapy after kidney transplantation. Tacrolimus dosing is challenged by considerable pharmacokinetic variability, both between patients and over time after transplantation, partly due to variability in cytochrome P450 3A (CYP3A) activity. The aim of this study was to assess the value of the endogenous CYP3A marker 4β-hydroxycholesterol (4βOHC) for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28146606
DOI: 10.1111/bcp.13248
PMCID: PMC5465334

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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