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Article

Pretransplant 4β-hydroxycholesterol does not predict tacrolimus exposure or dose requirements during the first days after kidney transplantation.

British journal of clinical pharmacology - 1 Nov 2017

Vanhove Thomas, Hasan Mahmoud, Annaert Pieter, Oswald Stefan, Kuypers Dirk R J

Abstract excerpt

AIMS: The CYP3A metric 4β-hydroxycholesterol (4βOHC) has been shown to correlate with tacrolimus steady-state apparent oral clearance (CL/F). Recently, pretransplant 4βOHC was shown not to predict tacrolimus CL/F after transplantation in a cohort of renal recipients (n = 79). The goal of the current study was determine whether these findings could be validated in a substantially larger cohort. METHODS: In a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28603840
DOI: 10.1111/bcp.13343
PMCID: PMC5651327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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