Article
Avoiding Tacrolimus Underexposure and Overexposure with a Dosing Algorithm for Renal Transplant Recipients: A Single Arm Prospective Intervention Trial.
Clinical pharmacology and therapeutics - 1 Jul 2021
Francke Marith I, Andrews Louise M, Le Hoang Lan, van de Wetering Jacqueline, Clahsen-van Groningen Marian C, van Gelder Teun, van Schaik Ron H N, van der Holt Bronno, de Winter Brenda C M, Hesselink Dennis A
Abstract excerpt
Bodyweight-based tacrolimus dosing followed by therapeutic drug monitoring is standard clinical care after renal transplantation. However, after transplantation, a meager 38% of patients are on target at first steady-state and it can take up to 3 weeks to reach the target tacrolimus predose concentration (C0 ). Tacrolimus underexposure and overexposure is associated with an increased risk of rejection and...
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