Article
The splice variant LOXIN inhibits LOX-1 receptor function through hetero-oligomerization.
Journal of molecular and cellular cardiology - 1 Mar 2008
Biocca Silvia, Filesi Ilaria, Mango Ruggiero, Maggiore Luana, Baldini Francesco, Vecchione Lucia, Viola Antonella, Citro Gennaro, Federici Giorgio, Romeo Francesco, Novelli Giuseppe
Abstract excerpt
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), encoded by the OLR1 gene, is a scavenger receptor that plays a central role in the pathogenesis of atherosclerosis. We have recently identified a truncated naturally occurring variant of the human receptor LOX-1, named LOXIN, which lacks part of the C-terminus lectin-like domain. In vivo and in vitro studies support that the new splicing isoform is...
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