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High levels of the AR-V7 Splice Variant and Co-Amplification of the Golgi Protein CodingYIPF6inARAmplified Prostate Cancer Bone Metastases

1 Feb 2017

Abstract excerpt

BACKGROUND: The relation between androgen receptor (AR) gene amplification and other mechanisms behind castration-resistant prostate cancer (CRPC), such as expression of constitutively active AR variants and steroid-converting enzymes has been poorly examined. Specific aim was to examine AR amplification in PC bone metastases and to explore molecular and functional consequences of this, with the long-term goal of...

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PMID: 28144969
DOI: 10.1002/pros.23307

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