Androgen Receptor Variant AR-V9 Is Coexpressed with AR-V7 in Prostate Cancer Metastases and Predicts Abiraterone Resistance.

doi:10.1158/1078-0432.CCR-17-0017

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Article

Androgen Receptor Variant AR-V9 Is Coexpressed with AR-V7 in Prostate Cancer Metastases and Predicts Abiraterone Resistance.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2017

Kohli Manish, Ho Yeung, Hillman David W, Van Etten Jamie L, Henzler Christine, Yang Rendong, Sperger Jamie M, Li Yingming, Tseng Elizabeth, Hon Ting, Clark Tyson, Tan Winston, Carlson Rachel E, Wang Liguo, Sicotte Hugues, Thai Ho, Jimenez Rafael, Huang Haojie, Vedell Peter T, Eckloff Bruce W, Quevedo Jorge F, Pitot Henry C, Costello Brian A, Jen Jin, Wieben Eric D, Silverstein Kevin A T, Lang Joshua M, Wang Liewei, Dehm Scott M

Abstract excerpt

Purpose: Androgen receptor (AR) variant AR-V7 is a ligand-independent transcription factor that promotes prostate cancer resistance to AR-targeted therapies. Accordingly, efforts are under way to develop strategies for monitoring and inhibiting AR-V7 in castration-resistant prostate cancer (CRPC). The purpose of this study was to understand whether other AR variants may be coexpressed with AR-V7 and promote...

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PMID: 28473535
DOI: 10.1158/1078-0432.CCR-17-0017
PMCID: PMC5644285

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