Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer

doi:10.1038/ncomms12008

Article

Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer

22 Jun 2016

Abstract excerpt

Genomic alterations in metastatic prostate cancer remain incompletely characterized. Here we analyse 493 prostate cancer cases from the TCGA database and perform whole-genome plasma sequencing on 95 plasma samples derived from 43 patients with metastatic prostate cancer. From these samples, we identify established driver aberrations in a cancer-related gene in nearly all cases (97.7%), including driver gene...

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