Article

AR-V7 Positivity Varies with Circulating Tumor Cell (CTC) Enrichment and Novel CTC Enrichment Is Able to Reduce AR-V7 False Positivity

2020-02-20

Abstract excerpt

<h4>Background: </h4> The AR-V7 splice variant is a cause of castration-resistant prostate cancer (CRPC). However, testing for the presence of AR-V7 by RT-PCR shows AR-V7 positivity in healthy individuals. We hypothesized that the positivity reflected contamination by hematopoietic cells. We tried a novel CTC enrichment instrument using Celsee® to clear hematopoietic cells. <h4>Methods:</h4> We tested whole bl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c1a7a652-3e40-5be1-91f8-5c20d076400a
DOI: 10.20944/preprints202002.0286.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

AR-V7 Positivity Varies with Circulating Tumor Cell (CTC) Enrichment and Novel CTC Enrichment Is Able to Reduce AR-V7 False PositivityDOI 10.20944/preprints202002.0286.v1Read

CTC-derived AR-V7 detection as a prognostic and predictive biomarker in advanced prostate cancer.Semantic proximity Read

An In-Depth Evaluation of the Validity and Logistics Surrounding the Testing of AR-V7 mRNA Expression in Circulating Tumor Cells.Semantic proximity Read

Androgen receptor variant 7 (AR-V7) in sequencing therapeutic agents for castratrion resistant prostate cancer: A critical review.Semantic proximity Read

Androgen receptor splice variant-7 expression emerges with castration resistance in prostate cancerSemantic proximity Read

Urinary Exosome Based Androgen Receptor Variant 7 Detection in Metastatic Castration Resistant Prostate Cancer PatientSemantic proximity Read

AR Splicing Variants and Resistance to AR Targeting AgentsSemantic proximity Read

The Clinicopathological Characteristics of Androgen Receptor Splicing Variant 7 (AR-V7) Expression in Patients with Castration Resistance Prostate Cancer: A Systematic Review and Meta‐AnalysisSemantic proximity Read

Assessment of Androgen Receptor splice variant-7 as a biomarker of clinical response in castration-sensitive prostate cancerSemantic proximity Read

Androgen Receptor Splice Variant 7 and Efficacy of Taxane Chemotherapy in Patients With Metastatic Castration-Resistant Prostate Cancer.Semantic proximity Read

AR-V7 in Metastatic Prostate Cancer: A Strategy beyond Redemption.Semantic proximity Read

Androgen Receptor Splice Variant 7 Detected by Immunohistochemical Is an Independent Poor Prognostic Marker in Men Receiving Adjuvant Androgen-Deprivation Therapy After Radical ProstatectomySemantic proximity Read

[The impact of the androgen receptor splice variant AR-V7 on the prognosis and treatment of advanced prostate cancer].Semantic proximity Read