Article
Phenotypic and genetic heterogeneity of tumor tissue and circulating tumor cells in patients with metastatic castration-resistant prostate cancer: A report from the PETRUS prospective study.
Oncotarget - 23 Aug 2016
Massard Christophe, Oulhen Marianne, Le Moulec Sylvestre, Auger Nathalie, Foulon Stéphanie, Abou-Lovergne Aurélie, Billiot Fanny, Valent Alexander, Marty Virginie, Loriot Yohann, Fizazi Karim, Vielh Philippe, Farace Francoise
Abstract excerpt
Molecular characterization of cancer samples is hampered by tumor tissue availability in metastatic castration-resistant prostate cancer (mCRPC) patients. We reported the results of prospective PETRUS study of biomarker assessment in paired primary prostatic tumors, metastatic biopsies and circulating tumor cells (CTCs). Among 54 mCRPC patients enrolled, 38 (70%) had biopsies containing more than 50% tumour...
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