Article

Tumor-Derived miR-378a-3p-Containing Extracellular Vesicles Promote Osteolysis by Activating a Dyrk1a/Nfatc1/Angptl2 Axis for Bone Metastasis

2021-07-10

Abstract excerpt

<h4>Background: </h4> The majority of the deaths of prostate cancer (PCa) are caused by progression to bone metastatic PCa. The importance of extracellular vesicles (EVs) in the formation of the pre-metastatic niche has been demonstrated in recent years. However, whether and how tumor-derived EVs interact with bone marrow macrophages (BMMs) to release EV-delivered microRNAs to promote osteolysis and to activate pr...

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Literature Corpus work: afb3a54d-fa24-5ca1-b748-87b5ae16029c
DOI: 10.21203/rs.3.rs-687415/v1

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