Article
The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer.
The EMBO journal - 8 Jul 2009
Malladi Srinivas, Challa-Malladi Madhavi, Fearnhead Howard O, Bratton Shawn B
Abstract excerpt
During stress-induced apoptosis, the initiator caspase-9 is activated by the Apaf-1 apoptosome and must remain bound to retain significant catalytic activity. Nevertheless, in apoptotic cells the vast majority of processed caspase-9 is paradoxically observed outside the complex. We show herein that apoptosome-mediated cleavage of procaspase-9 occurs exclusively through a CARD-displacement mechanism, so that...
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