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Article

Mutation in erythroid specific transcription factor KLF1 causes Hereditary Spherocytosis in the Nan hemolytic anemia mouse model.

Genomics - 1 Nov 2010

Heruth Daniel P, Hawkins Troy, Logsdon Derek P, Gibson Margaret I, Sokolovsky Inna V, Nsumu Ndona N, Major Stephanie L, Fegley Barbara, Woods Gerald M, Lewing Karen B, Neville Kathleen A, Cornetta Kenneth, Peterson Kenneth R, White Robert A

Abstract excerpt

KLF1 regulates definitive erythropoiesis of red blood cells by facilitating transcription through high affinity binding to CACCC elements within its erythroid specific target genes including those encoding erythrocyte membrane skeleton (EMS) proteins. Deficiencies of EMS proteins in humans lead to the hemolytic anemia Hereditary Spherocytosis (HS) which includes a subpopulation with no known genetic defect. Here...

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Share to Anemia, Hemolytic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kruppel-Like Transcription Factors

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Source

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Identifiers

PMID: 20691777
DOI: 10.1016/j.ygeno.2010.07.009
PMCID: PMC6390478

Genes

KLF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutation in erythroid specific transcription factor KLF1 causes Hereditary Spherocytosis in the Nan hemolytic anemia mouse model.PMID 20691777Read ↗

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