Article
Fast and accurate mutation detection in whole genome sequences of multiple isogenic samples with IsoMut.
BMC bioinformatics - 31 Jan 2017
Pipek O, Ribli D, Molnár J, Póti Á, Krzystanek M, Bodor A, Tusnády G E, Szallasi Z, Csabai I, Szüts D
Abstract excerpt
BACKGROUND: Detection of somatic mutations is one of the main goals of next generation DNA sequencing. A wide range of experimental systems are available for the study of spontaneous or environmentally induced mutagenic processes. However, most of the routinely used mutation calling algorithms are not optimised for the simultaneous analysis of multiple samples, or for non-human experimental model systems with no...
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