Article
Genome-wide mutation detection by interclonal genetic variation.
Mutation research. Genetic toxicology and environmental mutagenesis - 1 Jan 2000
Revollo Javier R, Dad Azra, McDaniel Lea P, Pearce Mason G, Dobrovolsky Vasily N
Abstract excerpt
Genetic toxicology assays estimate mutation frequencies by phenotypically screening for the activation or inactivation of endogenous or exogenous reporter genes. These reporters can only detect mutations in narrow areas of the genome and their use is often restricted to certain in vitro and in vivo models. Here, we show that Interclonal Genetic Variation (ICGV) can directly identify mutations genome-wide by...
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