Article
A 45-SNP genetic risk score is increased in early-onset coronary artery disease but independent of familial disease clustering.
Atherosclerosis - 1 Feb 2017
Christiansen Morten K, Nyegaard Mette, Pedersen Lisbeth N, Larsen Sanne B, Würtz Morten, Hjort Jakob, Kristensen Steen D, Jensen Henrik K
Abstract excerpt
BACKGROUND AND AIMS: Common genetic risk variants may contribute to the heritability of early-onset coronary artery disease (CAD). We aimed to investigate the association of a genetic risk score (GRS) with age upon CAD-onset and to test the association between the GRS, familial clustering, and CAD severity in early-onset CAD. METHODS: 134 early-onset CAD patients (<40 years), 446 late-onset CAD patients (male >55...
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