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A new model of sperm nuclear architecture following assessment of the organization of centromeres and telomeres in three-dimensions

31 Jan 2017

Abstract excerpt

The organization of chromosomes in sperm nuclei has been proposed to possess a unique "hairpin-loop" arrangement, which is hypothesized to aid in the ordered exodus of the paternal genome following fertilization. This study simultaneously assessed the 3D and 2D radial and longitudinal organization of telomeres, centromeres, and investigated whether chromosomes formed the same centromere clusters in sperm cells....

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PMID: 28139771
DOI: 10.1038/srep41585

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