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Article

Cardiolipin promotes electron transport between ubiquinone and complex I to rescue PINK1 deficiency.

The Journal of cell biology - 6 Mar 2017

Vos Melissa, Geens Ann, Böhm Claudia, Deaulmerie Liesbeth, Swerts Jef, Rossi Matteo, Craessaerts Katleen, Leites Elvira P, Seibler Philip, Rakovic Aleksandar, Lohnau Thora, De Strooper Bart, Fendt Sarah-Maria, Morais Vanessa A, Klein Christine, Verstreken Patrik

Abstract excerpt

PINK1 is mutated in Parkinson's disease (PD), and mutations cause mitochondrial defects that include inefficient electron transport between complex I and ubiquinone. Neurodegeneration is also connected to changes in lipid homeostasis, but how these are related to PINK1-induced mitochondrial dysfunction is unknown. Based on an unbiased genetic screen, we found that partial genetic and pharmacological inhibition of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28137779
DOI: 10.1083/jcb.201511044
PMCID: PMC5346965

Genes

PINK1
FASN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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