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Article

Inhibition of ACSL4 Alleviates Parkinsonism Phenotypes by Reduction of Lipid Reactive Oxygen Species.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics - 1 Jul 2023

Tang Fei, Zhou Liu-Yao, Li Ping, Jiao Ling-Ling, Chen Kang, Guo Yu-Jie, Ding Xu-Long, He Si-Yu, Dong Biao, Xu Ru-Xiang, Xiong Huan, Lei Peng

Abstract excerpt

Ferroptosis is a programmed cell death pathway that is recently linked to Parkinson's disease (PD), where the key genes and molecules involved are still yet to be defined. Acyl-CoA synthetase long-chain family member 4 (ACSL4) esterifies polyunsaturated fatty acids (PUFAs) which is essential to trigger ferroptosis, and is suggested as a key gene in the pathogenesis of several neurological diseases including...

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Identifiers

PMID: 37133631
DOI: 10.1007/s13311-023-01382-4
PMCID: PMC10457271

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