Article

Saturated cardiolipins are potent disruptors of inner mitochondrial membrane structure and function

2026-04-17

Abstract excerpt

Cardiolipin (CL) is a four-chained, mitochondrial-specific phospholipid crucial for maintenance of inner mitochondrial membrane (IMM) structure and function. In healthy tissues, CL acyl chains are highly unsaturated and maintained by a conserved remodeling pathway. However, dysregulation of CL acyl chain composition can arise from mutations in the CL transacylase, Tafazzin (TAZ), resulting in Barth syndrome (BTHS)...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6251179c-ea07-5cbc-b17a-2442675486b4
DOI: 10.64898/2026.04.14.718012

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Saturated cardiolipins are potent disruptors of inner mitochondrial membrane structure and functionDOI 10.64898/2026.04.14.718012Read

The Role of Cardiolipin in Cardiovascular HealthSemantic proximity Read

Cardiolipin Remodeling Defects Impair Mitochondrial Architecture and Function in a Murine Model of Barth Syndrome Cardiomyopathy.Semantic proximity Read

Expression of human monolysocardiolipin acyltransferase-1 improves mitochondrial function in Barth syndrome lymphoblasts.Semantic proximity Read

Tafazzin-Mediated Cardiolipin Remodeling Controls Metabolic Stress Response and Effector Function of Inflammatory T CellsSemantic proximity Read

Long-chain fatty acid oxidation and respiratory complex I deficiencies distinguish Barth Syndrome from idiopathic pediatric cardiomyopathy.Semantic proximity Read

Barth syndrome cellular models have dysregulated respiratory chain complex I and mitochondrial quality control due to abnormal cardiolipinSemantic proximity Read

Barth Syndrome: Connecting Cardiolipin to Cardiomyopathy.Semantic proximity Read

The functions of cardiolipin in cellular metabolism-potential modifiers of the Barth syndrome phenotype.Semantic proximity Read

The lipid environment modulates cardiolipin and phospholipid constitution in wild type and tafazzin-deficient cells.Semantic proximity Read

Barth syndrome: cardiolipin, cellular pathophysiology, management, and novel therapeutic targets.Semantic proximity Read

Cardiolipin dynamics promote membrane remodeling by mitochondrial OPA1Semantic proximity Read

Cardiolipin remodeling maintains the inner mitochondrial membrane in cells with saturated lipidomesSemantic proximity Read