Article
Bioenergetic consequences of PINK1 mutations in Parkinson disease.
PloS one - 1 Jan 2011
Abramov Andrey Yurevich, Gegg Matthew, Grunewald Anne, Wood Nicholas William, Klein Christine, Schapira Anthony Henry Vernon
Abstract excerpt
BACKGROUND: Mutations of the gene for PTEN-induced kinase 1 (PINK1) are a cause of familial Parkinson's disease (PD). PINK1 protein has been localised to mitochondria and PINK1 gene knockout models exhibit abnormal mitochondrial function. The purpose of this study was to determine whether cells derived from PD patients with a range of PINK1 mutations demonstrate similar defects of mitochondrial function, whether...
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