SLP-2 interacts with Parkin in mitochondria and prevents mitochondrial dysfunction in Parkin-deficient human iPSC-derived neurons and Drosophila.

doi:10.1093/hmg/ddx132

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Article

SLP-2 interacts with Parkin in mitochondria and prevents mitochondrial dysfunction in Parkin-deficient human iPSC-derived neurons and Drosophila.

Human molecular genetics - 1 Jul 2017

Zanon Alessandra, Kalvakuri Sreehari, Rakovic Aleksandar, Foco Luisa, Guida Marianna, Schwienbacher Christine, Serafin Alice, Rudolph Franziska, Trilck Michaela, Grünewald Anne, Stanslowsky Nancy, Wegner Florian, Giorgio Valentina, Lavdas Alexandros A, Bodmer Rolf, Pramstaller Peter P, Klein Christine, Hicks Andrew A, Pichler Irene, Seibler Philip

Abstract excerpt

Mutations in the Parkin gene (PARK2) have been linked to a recessive form of Parkinson's disease (PD) characterized by the loss of dopaminergic neurons in the substantia nigra. Deficiencies of mitochondrial respiratory chain complex I activity have been observed in the substantia nigra of PD patients, and loss of Parkin results in the reduction of complex I activity shown in various cell and animal models. Using...

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PMID: 28379402
DOI: 10.1093/hmg/ddx132
PMCID: PMC6192413

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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