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Article

Differentiated State of Initiating Tumor Cells Is Key to Distinctive Immune Responses Seen in H-RasG12V-Induced Squamous Tumors.

Cancer immunology research - 1 Mar 2017

Podolsky Michael A, Bailey Jacob T, Gunderson Andrew J, Oakes Carrie J, Breech Kyle, Glick Adam B

Abstract excerpt

Heterogeneity in tumor immune responses is a poorly understood yet critical parameter for successful immunotherapy. In two doxycycline-inducible models where oncogenic H-RasG12V is targeted either to the epidermal basal/stem cell layer with a Keratin14-rtTA transgene (K14Ras), or committed progenitor/suprabasal cells with an Involucrin-tTA transgene (InvRas), we observed strikingly distinct tumor immune...

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Identifiers

PMID: 28137717
DOI: 10.1158/2326-6066.CIR-16-0304
PMCID: PMC5341741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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