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Article

Defining the origins of Ras/p53-mediated squamous cell carcinoma.

Proceedings of the National Academy of Sciences of the United States of America - 3 May 2011

White Andrew C, Tran Kathy, Khuu Joan, Dang Christine, Cui Yongyan, Binder Scott W, Lowry William E

Abstract excerpt

The precise identity of cancer cells of origin and the molecular events of tumor initiation in epidermal squamous cell carcinoma (SCC) are unknown. Here we show that malignancy potential is related to the developmental capacity of the initiating cancer cell in a genetically defined, intact, and inducible in vivo model. Specifically, these data demonstrate that SCCs can originate from inside the hair follicle stem...

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Share to Carcinoma, Squamous Cell
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to ras Proteins

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Source

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Identifiers

PMID: 21502519
DOI: 10.1073/pnas.1012670108
PMCID: PMC3088581

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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